Japan medical spas, spa medicine, medical hydrology, balneology, balneotherapy

Assoc. Prof. F. Mitsunobu

Division of Medicine, Misasa Medical Branch,
Okayama University Medical School

STAFF

Yoshiro Tanizaki, MD, PhD, Professor
Fumihiro Mitsunobu, MD, PhD, Associate Professor
Kozo Ashida, MD, PhD, Lecturer
Yasuhiro Hosaki, MD, PhD, Lecturer
Hirofumi Tsugeno, MD, PhD
Takuya Nagata, MD
Tadashi Yokoi, MD, PhD

RESEARCH PROJECTS

To clarify the action mechanisms of spa therapy
To clarify the pathophysiology of bronchial asthma and COPD in elderly
Study the clinical effects of dietary supplementation with n-3 fatty acid
Study on steroid-induced osteoporosis

PROFESSIONAL AFFILIATIONS

Japanese Society of Internal Medicine
Japanese Association of Physical Medicine, Balneology and Climatology
Japanese Respiratory Society
Japan Geriatrics Society
Japanese Society of Allergology

PUBLICATIONS (SPA MEDICINE DATABASE)

Vu K, Mitsunobu F.
Spa Therapy for Bronchial Asthma: Studies at the Misasa Medical Center
Alternative & Complementary Therapies 2004 June, 10(3): 144- 150.

Yamaoka K, Mitsunobu F, Hanamoto K, Shibuya K, Mori S, Tanizaki Y, Sugita K.
Biochemical Comparison between Radon Effects and Thermal Effects on Humans in Radon Hot Spring Therapy
J Radiat Res (Tokyo). 2004 Mar;45(1):83-8.
http://www.jstage.jst.go.jp/article/jrr/45/1/83/_pdf

Yamaoka K, Mitsunobu F, Hanamoto K, Mori S, Tanizaki Y, Sugita K.
Study on biologic effects of radon and thermal therapy on osteoarthritis.
J Pain. 2004 Feb;5(1):20-5.

Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Tanizaki Y, Tanimoto M.
Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma.
Clin Exp Allergy. 2004 Jan;34(1):59-64.

Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki Y.
Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma.
J Radiat Res (Tokyo). 2003 Jun;44(2):95-9. http://www.jstage.jst.go.jp/article/jrr/44/2/95/_pdf

Okamoto M, Ashida K, Mitsunobu F, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi T, Takata S, Tanizaki Y.
Effects of spa therapy combined with dietary supplementation with n-3 fatty acids on bronchial asthma.
J Jpn Assoc Phys Med Balneol Climatol 2003; 66: 171-179.

Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Tanizaki Y.
Decreased computed tomographic lung density during exacerbation of asthma.
Eur Respir J. 2003 Jul;22(1):106-12.

Tsugeno H, Mizuno M, Fujiki S, Okada H, Okamoto M, Hosaki Y, Ashida S, Mitsunobu F, Tanizaki Y, Shiratori Y.
A proton-pump inhibitor, rabeprazole, improves ventilatory function in patients with asthma associated with gastroesophageal reflux.
Scand J Gastroenterol. 2003 May;38(5):456-61.

Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida K, Takata S, Yokoi T, Mishima M, Tanizaki Y.
Complexity of terminal airspace geometry assessed by computed tomography in asthma.
Am J Respir Crit Care Med 2003 Feb 1;167(3):411-7 http://ajrccm.atsjournals.org/cgi/reprint/167/3/411.pdf

Ashida K, Mitsunobu F, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi T, Tanizaki Y.
Decrease in low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) by long-term spa therapy in patients with asthma.
J Jpn Assoc Phys Med Balneol Climatol 2003; 66: 115-122

Mitsunobu F, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi T, Tanizaki Y.
Long-term spa therapy prevents the progressive pathological changes of the lung in patients with pulmonary emphysema.
J Jpn Assoc Phys Med Balneol Climatol 2003; 66: 91-98

Tsugeno H, Tsugeno H, Fujita T, Goto B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y.
Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis. Osteoporos Int 2002 Aug;13(8):650-6.

Yamaoka K, Mifune T, Mitsunobu F, Kojima S, Mori S, Shibuya K, Tanizaki Y, Sugita K. Basic study on radon effects and thermal effects on humans in radon therapy.
Physiol Chem Phys Med NMR 2001;33(2):133-8.

Mitsunobu F, Mifune T, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y.
Influence of age and disease severity on high resolution CT lung densitometry in asthma. Thorax 2001 Nov;56(11):851-6. http://thorax.bmjjournals.com/cgi/reprint/56/11/851.pdf

Mitsunobu F, Mifune T, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Harada S, Tanizaki Y. Low-attenuation areas of the lungs on high-resolution computed tomography in asthma.
J Asthma 2001 Aug;38(5):413-22.

Ashida K, Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi T, Tanizaki Y.
Effect of spa therapy on low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) and pulmonary function in patients with asthma.
J Jpn Assoc Phys Med Balneol Climatol 2001; 64: 203-209

Tsugeno H, Goto B, Fujita T, Okamoto M, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tsuji T, Tanizaki Y.
Oral glucocorticoid-induced fall in cortical bone volume and density in postmenopausal asthmatic patients.
Osteoporos Int 2001;12(4):266-70.

Takata S, Harada S, Mitsunobu F, Mifune T, Hosaki Y, Asida K, Tsugeno H, Okamoto M, Iwahashi M, Kawashima M, Yamamura M, Makino H, Tanizaki Y.
A patient with severe palindromic rheumatism and frequent episodes of pain.
Intern Med 2001 Feb;40(2):140-3.

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Takata S, Tanizaki Y. Enhanced production of leukotrienes by peripheral leukocytes and specific IgE antibodies in patients with chronic obstructive pulmonary disease.
J Allergy Clin Immunol 2001 Mar;107(3):492-8.

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y, Harada M.
Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics.
Eur Respir J 2000 Sep;16(3):504-8.

Okamoto M, Mitsunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, Harada S, Tanizaki Y, Kataoka M, Niiya K, Harada M.
Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism.
Int Arch Allergy Immunol 2000 Jun;122(2):137-42.

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Tanizaki Y. IgE-mediated and age-related bronchial hyperresponsiveness in patients with asthma. relationship to family history of the disease.
Age Ageing 2000 May;29(3):215-20. http://ageing.oupjournals.org/cgi/reprint/29/3/215.pdf

Okamoto M, Mitsunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, Harada S, Tanizaki Y. Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma.
Intern Med 2000 Feb;39(2):107-11.

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y.
Effects of spa therapy on pulmonary emphysema in relation to IgE-mediated allergy.
J Jpn Assoc Phys Med Balneol Climatol 2000; 63: 120-126

Ashida K, Mitsunobu F, Hosaki Y, Mifune T, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y.
Clinical effects of spa therapy on patients with asthma accompanied by emphysematous changes.
J Jpn Assoc Phys Med Balneol Climatol 2000; 63: 113-119

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Tanizaki Y. Improvement of pulmonary function by spa therapy in patients with emphysema, evaluated by residual volumen (RV) and low attenuation area (LAA) of high resolution computed tomography (HRCT).
J Jpn Assoc Phys Med Balneol Climatol 1999; 62: 121-128

Tsugeno H, Nakai M, Okamoto M, Harada S, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tanizaki Y, Tsuji T.
Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography.
Eur Respir J 1999 Oct;14(4):923-7.

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Tanizaki Y. Effects of spa therapy on patients with pulmonary emphysema- relationship to disease severity evaluated by low attenuation area of the lung on high resolution computed tomography (HRCT).
J Jpn Assoc Phys Med Balneol Climatol 1998; 61: 79-86

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Yokota S, Tsugeno H, Tanizaki Y.
Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma.
J Asthma 1998;35(4):367-72.

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Tanizaki Y. Antiallergic action of spa therapy on patients with asthma sensitive to house dust mite.
J Jpn Assoc Phys Med Balneol Climatol 1998; 61: 177-183

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Yokota S, Tsugeno H, Tanizaki Y.
Association of spa effects with generation of leukotrienes B4 and C4 by leukocytes in patients with asthma.
J Jpn Assoc Phys Med Balneol Climatol 1997; 60: 141-148

Mifune T, Mitsunobu F, Hosaki Y, et al.
Effects of spa therapy on patients with type II (bronchiolar obstruction) asthma. Relationship to bronchoalveolar neutrophilia.
J Jpn Assoc Phys Med Balneol Climatol 1997; 60: 117-124

Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Yokota S, Tsugeno H, Tanizaki Y.
Effects of spa therapy on asthmatics with low ventilatory function- relationship to asthma type, patient age, and airway inflammation.
J Jpn Assoc Phys Med Balneol Climatol 1997; 60: 125-132

Mifune T, Mitsunobu F, Hosaki Y, Yokota S, Tanizaki Y.
Spa therapy and function of adrenocortical glands in patients with steroid-dependent intractable asthma (SDIA)- relationship to clinical asthma type, patient age, and clinical efficacy.
J Jpn Assoc Phys Med Balneol Climatol 1996; 59: 133-140

Hosaki Y, Mifune T, Unobu F, et al.
Mits Reduction of glucocorticoids by spa therapy in patients with steroid-dependent intractable asthma (SDIA).
J Jpn Assoc Phys Med Balneol Climatol 1996; 59: 201-208

Mitsunobu F, Mifune T, Hosaki Y, Yokota S, Tanizaki Y.
Improvement of forced vital capacity (FVC) by spa therapy in patients with bronchial asthma. J Jpn Assoc Phys Med Balneol Climatol 1996; 59: 218-224

Mitsunobu F, Mifune T, Kajimoto K, Yokota S, Kitani H, Tanizaki Y.
Effects of spa therapy on immune system in patients with bronchial asthma.
J Jpn Assoc Phys Med Balneol Climatol 1995; 58: 180-186

Mitsunobu F, Mifune T, Kajimoto K, Yokota S, Tanizaki Y.
Improvement of bronchial sensitivity by spa therapy in patients with asthma.
J Jpn Assoc Phys Med Balneol Climatol 1995; 58: 241-248

Tanizaki Y, Kitani H, Mifune T, et al.
Effects of spa therapy on psychological factors in patients with bronchial asthma.
J Jpn Assoc Phys Med Balneol Climatol 1995; 61: 153-159

Kajimoto K, Mifune T, Mitsunobu F, et al. Serum cortisol levels after 20 minute bathing suggest the function of adrenocortical glands in patients with bronchial asthma.
J Jpn Assoc Phys Med Balneol Climatol 1995; 58: 218-224

Mifune T, Yokota S, Kajimoto K, et al.
Effects of spa theray on endocrine-autonomic nerve system in patients with bronchial asthma. J Jpn Assoc Phys Med Balneol Climatol 1995; 58: 225-230

Tanizaki Y, Kitani H, Mifune T, Mitsunobu F.
Action mechanisms of spa therapy in patients with chronic obstructive pulmonary disease (COPD).
J Jpn Assoc Phys Med Balneol Climatol 1994; 57: 183-190

Tanizaki Y, Kitani H, Mifune T, et al.
Ten-year study on spa therapy in 329 patients with bronchial asthma.
J Jpn Assoc Phys Med Balneol Climatol 1994; 57: 142-150

Mitsunobu F, Kitani H, Mifune T, Kajimoto K, Nakagiri Y, Tanizaki Y.
Clinical effects of spa therapy on bronchial asthma. 12. Effects on asthma with hypersecretion.
J Jpn Assoc Phys Med Balneol Climatol 1993; 56: 203-210

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Nakagiri N, Ochi K, Harada H, Takahashi K, Kimura I.
Clinical effects of spa therapy on bronchial asthma. 11. Effects on asthma in the elderly.
J Jpn Assoc Phys Med Balneol Climatol 1993; 56: 195-202

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Okuda H, Ochi K, Harada H, Takahashi K, Kimura I.
Clinical effects of spa therapy on bronchial asthma. 9. Suppression of bronchial hyperresponsiveness.
J Jpn Assoc Phys Med Balneol Climatol 1993; 56: 135-142

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Ochi K, Harada H, Kimura I. Clinical effects of spa therapy on bronchial asthma. 7. relationship between spa effects and airway inflammation.
J Jpn Assoc Phys Med Balneol Climatol 1993; 56: 79-86

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Okano T, Honke N, Kimura I.
A new modified classification of bronchial asthma based on clinical symptoms.
Internal Medicine 1993; 32: 197-203

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Kimura I.
Effects of long-term glucocorticoid therapy on bronchoalveolar cells in adult patients with bronchial asthma.
J Asthma 30: 309-318, 1993

Tanizaki Y, Kitani H, Mifune T, Mitsunoby F, Kajimoto K, Sugimoto K.
Effects of glucocorticoids on humoral and cellular immunity and on airway inflammation in patients with steroid-dependent intractable asthma.
J Asthma 30: 458-482, 1993

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Kimura I.
Changes in the proportion of bronchoalveolar lymphocytes, neutrophils and basophilic cells and the release of histamine and leukotrienes from broncholalveolar cells in patients with steroid-dependent intractable asthma.
Int Arch Allergy Immunol 101; 196-202, 1993

Tanizaki Y, Kitani H, Okazaki M, et al.
Airway inflammation and bronchial hyperresponsiveness in patients with asthma. Comparison between atopic and nonatopic asthma.
Jpn J Allergol 42: 26-33, 1993

Tanizaki Y, Kitani H, Okazaki M, et al.
Characteristics of airway responses in patients with bronchial asthma. Evaluation of asthma classification system based on clinical symptoms and clinical findings.
Jpn J Allergol 42: 123-130, 1993

Tanizaki Y, Kitani H, Okazaki M, et al.
Mucus hypersecretion and eosinophils in bronchoalveolar lavage fluid in adult patients with asthma.
J Asthma 30: 257-262, 1993

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Nakagiri Y, Ochi K, Harada H, Takahashi K, Kimura I.
Clinical effects of spa therapy on bronchial asthma. 10. Effects on asthma with bronchiolar obstruction.
J Jpn Assoc Phys Med Balneol Climatol 1993; 56: 143-150

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Okuda H, Ochi K, Harada H, Takahashi K, Kimura I.
Clinical effects of spa therapy on bronchial asthma. 8. Effects on supressed function of adrenocortical glands.
J Jpn Assoc Phys Med Balneol Climatol 1993; 56: 87-94

Tanizaki Y, Kitani H, Mifune T, Mitsunobu F, Kajimoto K, Nakagiri Y, Ochi K, Harada H, Takahashi K, Kimura I.
Clinical effects of spa therapy on patients with chronic obstructive bronchiolitis.
J Jpn Assoc Phys Med Balneol Climatol 1993; 56: 211-219

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Honke N, Kimura I.
Clinical effects of complex spa therapy on patients with steroid-dependent intractable asthma (SDIA).
Jpn J Allergol 1993; 42: 219-227

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Ochi K, Harada H, Kimura I.
Spa therapy improves ventilatory function in the small airways of patients with steroid-dependent intractable asthma (SDIA).
Acta Med Okayama 1992; 46: 175-178

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Okuda H, Takatori A, Ochi K, Harada H.
Clinical effects of spa therapy on bronchial asthma. 2. Relationship to ventilatory function.
J Jpn Assoc Phys Med Balneol Climatol 1992; 55: 82-86

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Okuda H, Takatori A, Ochi K, Harada H.
Clinical effects of spa therapy on bronchial asthma. 1. Relationship to clinical asthma types and patient age.
J Jpn Assoc Phys Med Balneol Climatol 1992; 55: 77-81

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Okuda H, Ochi K, Harada H, Kimura I.
Clinical effects of spa therapy on bronchial asthma. 5. Efficacy of inhalation with iodine salt solution.
J Jpn Assoc Phys Med Balneol Climatol 1992; 55: 179-184

Mitsunobu F, Kitani H, Okazaki M, Mifune T, Okuda H, Tanizaki Y.
Clinical effects of spa therapy on bronchial asthma. 6. Comparison among three kinds of spa therapies.
J Jpn Assoc Phys Med Balneol Climatol 1992; 55: 185-190

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Takatori A, Okuda H, Ochi K, Harada H.
Clinical effects of spa therapy on bronchial asthma. 4. Effects on steroid-dependent intractable asthma (SDIA).
J Jpn Assoc Phys Med Balneol Climatol 1992; 55: 134-138

Kitani H, Mitsunobu F, Mifune T, Okazaki M, Tanizaki Y.
Clinical effects of spa therapy on bronchial asthma. 3. Efficacy of fango therapy.
J Jpn Assoc Phys Med Balneol Climatol 1992; 55: 127-133

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Kotoh N, Tada S, Takahashi K, Kimura I.
Asthma classification by score calculated from clinical findings and examinations. Comparison between clinical diagnosis and score diagnosis.
Jpn J Allergol 1992; 41: 489-496

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Ochi K, Harada H.
Cellular composition of fluid in the airways of patients with house dust sensitive asthma, classified by clinical symptoms.
Internal Medicine 1992; 31: 333-338

Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Honke N, Kimura I. Pathophysiological changes in the airways of asthma patients with aging.
Jpn J Allergol 41: 1380-1387, 1992

Tanizaki Y, Sudo M, Kitani H, Kawauchi K, Mifune T, Okuda h, Soda M, Takahashi K, Kimura I.
Clinical effects of spa therapy on patients with bronchial asthma. Comparison between immediate and distant effects of spa therapy.
J Jpn Assoc Phys Med Balneol Climatol 1990; 53: 147-152

Tanizaki Y, Sudo M, Kitani H, Kawauchi K, Mifune T, Takayama H, Kohi F, Tada S, Takahashi K, Kimura I.
Characteristic of cell components in bronchoalveolar lavage fluid (BALF) in patients with bronchial asthma classified by clinical symptoms.
Jpn J Allergol 1990; 39: 75-81

Tanizaki Y, Sudo M, Kitani H, et al.
Release of heparin-like substance and histamine from basophilic leucocytes separated by counterflow centrifugation elutriation.
Jpn J Med 29: 356-361, 1990

Tanizaki Y, Sudo M, Kitani H, Araki H, Oki K, Soda R, Tada S, Takahashi K, Kimaura I. Clinical studies on steroid-dependent intractable asthma. Comparison between early and late onset of asthma.
Jpn J. Allergol 38: 68-73, 1989

Tanizaki Y, Sudo M, Kitani H, Araki H, Oki K, Tsuji M, Takahashi K, Kimura I. Eosinophilic leucocytes and arylsulfatase activity in bronchoalveolar lavage fluid of patients with bronchial asthma.
Acta Med Okayama 1988; 42: 227-230

Tanizaki Y.
Improvement of ventilatory function by spa therapy in patients with intractable asthma.
Acta Med Okayama 1986; 40: 55-59

Tanizaki Y, Komagoe H, Sudo M, Morinaga H.
Clinical effects of spa therapy on steroid-dependent intractable asthma.
Z Physiother 1985; 37: 425-430

Tanizaki Y, Komagoe H, Sudo M, Morinaga H, Ohtani J, Kimura I.
Clinical effects of spa therapy on patients with bronchial asthma and characteristics of its action mechanisms.
J Jpn Assoc Phys Med Balneol Climatol 1985; 48: 99-103

Tanizaki Y, Komagoe H, Sudo M, Okada C, Morinaga H, Ohtani J, Kimura I.
Changes of ventilatory function in patients with bronchial asthma during swimming training in a hot spring pool.
J Jpn Assoc Phys Med Balneol Climatol 1984; 47: 99-104

Tanizaki Y, Komagoe H, Sudo M, Ohtani J, Kimura I.
Intractable asthma and swimming training in a hot spring pool.
J Jpn Assoc Phys Med Balneol Climatol 1984; 47: 115-122

Tanizaki Y, Komagoe H, Sudo M, Morinaga H, Ohtani J, Takahashi K, Kimura I.
Swimming training in a hot spring pool as therapy for steroid-dependent asthma.
Jpn J Allergol 1984; 33: 389-395

Tanizaki Y, Komagoe H, Sudo M, Morinaga H, Shiota Y, Tada S, Takahashi K, Kimura I. Classification of asthma based on clinical symptoms: asthma type in relation to patient age and age at onset of disease.
Acta Med Okayama 1984; 38: 471-477

Tanizaki Y, Komagoe H, Morinaga M, Kitani H, Goda Y, Kimura I.
Allergen and anti-IgE-induced histamine release from whole blood.
Int Arch Allergy Appllmmunol 43: 141-145, 1984

Tanizaki Y, Komagoe H, Sudo H, Kitani H, Goda H, Tada S, Takahashi K, Kimura I.
IgE-mediated histamine release from whole blood in atopic asthmatics.
Jpn J Allergol 32: 1079-1083, 1983